Selamectin

EINECS No.

815-979-7 

Molecular formula

C₄₃H₆₃NO₁₁

Molecular weight

769.967

Molecular structure

Application & advantage

Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic.  Selamectin activates glutamate -gated chloride channels in neurons and pharyngeal muscles to prevent heartworm, Lymphatic filariae, and nematode infection. Selamectin is also a potent P-glycoprotein substrate and a P-glycoprotein inhibitor with an IC₅₀ of 120 Nm.

Selamectin is a new generation of Avermectin derivatives, which is produced by Streptomyces Avermectin Fermentation. The results shows that the effect of Selamectin is similar as that of Avermectin.  Selamectin is safe and can be used in both dogs and cats as injection and oral. It can effect well through blood circulation to fight against mites, ascaris lumbricoides and heartworms. But it has little effect on ticks and fleas.